What question did this study set out to answer?

To examine how Bay K8644 affects calcium channel currents in heart cells at varying voltages.

Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644.

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To examine how Bay K8644 affects calcium channel currents in heart cells at varying voltages.
Investigated voltage-dependent effects of Bay K8644 on Ca channel currents in calf Purkinje fibers and rat ventricular myocytes.
Measured currents during depolarizing and hyperpolarizing voltage pulses with control comparisons.
Bay K8644 increases the rate of inactivation of calcium currents during depolarization.
Currents after hyperpolarization are larger with Bay K8644 than control, but smaller after positive conditioning pulses.
Observations align with kinetic model predictions related to a single drug-induced rate constant change.

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In vitro Ca channel data warrant no clinical change; leaves open voltage-dependent effects in intact myocardium.

Sanguinetti et al. (1986) studied this question.

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