Modulation of calcium channel currents in guinea‐pig single ventricular heart cells by the dihydropyridine Bay K 8644.
Population
Isolated ventricular cells from guinea-pig hearts
Comparison
1,4-dihydropyridine Bay K 8644 evaluated at 37… vs Baseline/control currents before application
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Provides mechanistic insight into ventricular Ca2+ channel gating in guinea-pig myocytes; leaves open translation to human electrophysiology.
Structured PICO
P
Population
Isolated ventricular cells from guinea-pig hearts
I
Intervention
1,4-dihydropyridine Bay K 8644 (5 mumol/l) evaluated at 37 degrees C
C
Comparator
Baseline/control currents before application
O
Outcome
Ba2+ peak currents and current-voltage relationshipssurrogate
Bay K 8644 modulates calcium channel currents in guinea-pig ventricular cells by increasing peak currents and shifting activation and inactivation towards hyperpolarizing potentials, consistent with a model of current-dependent inactivation.
Cite This Study
Markwárdt et al. (1988) studied this question.