August 1, 1984AJP Heart and Circulatory Physiology

New Ca2+ agonist (Bay K 8644) enhances and induces cardiac slow action potentials

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Why the study?

Does Bay K 8644 enhance Ca2+ influx and induce slow action potentials in isolated guinea pig papillary muscles?

Population

Isolated guinea pig papillary muscles

Comparison

Bay K 8644 (10(-6) M) vs Baseline conditions and reversal by nifedipine…

Design

Preclinical

Authors

GWGordon M. WahlerMidwestern University NSN. SperelakisUniversity of Maryland, Baltimore

Discussion

Member takes

Implication

Hypothesis-generating for Ca2+ channel agonism in myocardium; leaves open translation to human therapeutics.

Structured PICO

Does Bay K 8644 enhance Ca2+ influx and induce slow action potentials in isolated guinea pig papillary muscles?

Population

Isolated guinea pig papillary muscles

Intervention

Bay K 8644 (10(-6) M)

Comparator

Baseline conditions (fast Na+ channels inactivated by 25 mM K+, or slow action potentials induced by tetraethylammonium chloride plus Ca2+ or isoproterenol) and reversal by nifedipine (10(-6) M)

Outcome

Electrophysiological effects (induction and potentiation of Ca2+-dependent slow action potentials, maximal rate of rise [Vmax], and contractility)surrogate

Bay K 8644 acts as a Ca2+-channel stimulator, enhancing Ca2+ influx and inducing slow action potentials in myocardial tissue.

Cite This Study

Wahler et al. (1984) studied this question.

synapsesocial.com/papers/6a7190d2b5c1fe5ca9dfdcf8 https://doi.org/10.1152/ajpheart.1984.247.2.h337

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New Ca2+ agonist (Bay K 8644) enhances and induces cardiac slow action potentials

Discussion

Member takes

Implication

Structured PICO

Cite This Study

New Ca2+ agonist (Bay K 8644) enhances and induces cardiac slow action potentials

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider