Why the study?
Does Bay K 8644 exert a positive inotropic effect in rat and guinea-pig isolated cardiac preparations?
Population
Rat and guinea-pig isolated cardiac preparations (atria and ventricular strips)
Comparison
Bay K 8644 (nifedipine analogue) vs Nifedipine and varying external calcium…
Design
Preclinical
Authors
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Bay K 8644's positive inotropy in rodent myocardium supports dihydropyridine site research; leaves open in vivo or clinical translation.
Does Bay K 8644 exert a positive inotropic effect in rat and guinea-pig isolated cardiac preparations?
Bay K 8644 exerts a positive inotropic effect in isolated cardiac tissues by interacting with dihydropyridine binding sites.
Finet et al. (1985) studied this question.
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