Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1984Circulation ResearchOpen Access

Effects of Bay k 8644, a dihydropyridine analog, on 3Hnitrendipine binding to canine cardiac sarcolemma and the relationship to a positive inotropic effect.

View Full Paper
Ask AI
Bookmark
Share

Population

Canine cardiac sarcolemma preparations and isolated canine heart trabecular muscle

Design

Preclinical

Authors

PVPál L. VághyGyeongsang National UniversityIGIngrid L. GruppSabin Vaccine InstituteGGG. GruppUniversity of Freiburg

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for dihydropyridine modulation of contractility in isolated tissue; leaves open translation to human cardiac function.

Structured PICO

P
Population
Canine cardiac sarcolemma preparations and isolated canine heart trabecular muscle
I
Intervention
Bay k 8644 (calcium agonist) and nitrendipine (calcium antagonist)
O
Outcome
Equilibrium dissociation constants for [3H]nitrendipine binding and concentration producing a 50% change in contractile forcesurrogate

Binding of Bay k 8644 to high-affinity dihydropyridine-binding sites in canine cardiac sarcolemma is pharmacologically relevant and correlates with its positive inotropic effect.

Cite This Study

Vághy et al. (1984) studied this question.

synapsesocial.com/papers/6a716db3f44fa9f079df39b8https://doi.org/10.1161/01.res.55.4.549
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular Action of Calcium Channel Blocking Drugs1984 · 160 citations
  2. 2Decrease in Na+,K+-ATPase activity and [3H]ouabain binding sites in sarcolemma prepared from hearts of spontaneously hypertensive rats.1983 · 56 citations