February 1, 1986Journal of Biological ChemistryOpen Access

Voltage-sensitive nitrendipine binding in an isolated cardiac sarcolemma preparation.

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Population

Highly enriched sarcolemma preparation isolated from canine ventricle

Design

Preclinical

Authors

WSWilliam P. SchillingMetroHealth JDJürgen DreweUniversity of Basel

Discussion

Member takes

Implication

Voltage sensitivity of nitrendipine binding in canine membranes cautions against clinical extrapolation; leaves open mechanistic implications for dihydropyridine action.

Structured PICO

Population

Highly enriched sarcolemma preparation isolated from canine ventricle

Intervention

Nitrendipine binding evaluation under varying temperatures (20 and 37 degrees C) and membrane potentials

Outcome

Nitrendipine binding characteristics (dissociation constant [Kd], maximal binding capacity, and effect of membrane potential)surrogate

Nitrendipine binding in canine cardiac sarcolemma is voltage-sensitive, with binding affinity changing reversibly in response to membrane potential alterations.

Cite This Study

Schilling et al. (1986) studied this question.

synapsesocial.com/papers/6a86c94436c36f97809eb65b https://doi.org/10.1016/s0021-9258(17)35849-0

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Implication

Voltage sensitivity of nitrendipine binding in canine membranes cautions against clinical extrapolation; leaves open mechanistic implications for dihydropyridine action.

Voltage-sensitive nitrendipine binding in an isolated cardiac sarcolemma preparation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage-sensitive nitrendipine binding in an isolated cardiac sarcolemma preparation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider