November 1, 1995Journal of Biological ChemistryOpen Access

Molecular Determinants of Cardiac Ca2+ Channel Pharmacology

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Population

COS.M6 cells and Xenopus oocytes transfected with cardiac L-type Ca2+ channel subunits

Comparison

Coexpression of different subunit combinations… vs Different subunit combinations and cardiac…

Design

Preclinical

Authors

XWXiangyang WeiFirst Affiliated Hospital of Zhengzhou University SPSu PanBaylor College of Medicine WLWenhua LangWeifang Medical University

Discussion

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Implication

Alpha2 may guide future channel modulator design; leaves open clinical translation in human cardiac disease.

Structured PICO

Population

COS.M6 cells and Xenopus oocytes transfected with cardiac L-type Ca2+ channel subunits (alpha 1C, alpha 2 delta, beta 2, gamma)

Intervention

Coexpression of different subunit combinations (alpha 1, beta, alpha 2, gamma) and exposure to dihydropyridines (PN200-110, nisoldipine), (-)-D600, and diltiazem

Comparator

Different subunit combinations (e.g., alpha 1 + beta vs alpha 1 + beta + alpha 2) and cardiac membranes/microsomes

Outcome

Dihydropyridine binding affinity, allosteric regulation, and inhibition of Ca2+ channel currentssurrogate

The alpha 2 subunit is an essential component of the cardiac L-type Ca2+ channel, required for normal dihydropyridine binding and allosteric regulation.

Cite This Study

Wei et al. (1995) studied this question.

synapsesocial.com/papers/6a725e5b84cc45bb7be01c33 https://doi.org/10.1074/jbc.270.45.27106

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Molecular Determinants of Cardiac Ca2+ Channel Pharmacology

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Determinants of Cardiac Ca2+ Channel Pharmacology

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider