Key result
The Ca(v)beta(1d) isoform is expressed in the heart and increases the mean open probability of L-type Ca2+ channels four- to fivefold, but does not promote membrane trafficking of the channel complex.
The short auxiliary Ca(v)beta(1d) subunit is expressed in cardiac muscle and modulates L-type Ca2+ channel gating without promoting membrane trafficking.
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Does not support immediate clinical translation; hypothesis-generating for beta-subunit modulation of cardiac calcium channels.
Cohen et al. (2004) studied this question. Ca(v)beta(1d) subunit coexpression vs. alpha1C-channels alone or Ca(v)beta(1b) coexpression was evaluated on Membrane trafficking and gating of L-type Ca2+ channels. The Ca(v)beta(1d) isoform is expressed in the heart and increases the mean open probability of L-type Ca2+ channels four- to fivefold, but does not promote membrane trafficking of the channel complex.
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