Why the study?
Does the beta 3 subunit modulate the block of the expressed L-type calcium channel by different classes of organic calcium channel blockers in Chinese hamster ovary cells?
Population
Chinese hamster ovary cells expressing the alpha 1C subunit of the L-type calcium channel alone or in…
Comparison
Co-expression of the beta 3 subunit and… vs Expression of the alpha 1C subunit alone
Design
Preclinical
Authors
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Beta 3 subunit selectively modulates phenylalkylamine but not dihydropyridine block of L-type channels; leaves open clinical relevance pending in vivo studies.
Does the beta 3 subunit modulate the block of the expressed L-type calcium channel by different classes of organic calcium channel blockers in Chinese hamster ovary cells?
The beta 3 subunit distinctly affects the interaction of the alpha 1C subunit of the L-type calcium channel with different classes of organic calcium channel blockers.
Lacinová et al. (1995) studied this question.
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