Modulation of acetylcholine‐activated K+ channel function in rat atrial cells by phosphorylation.

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Population

Rat neonatal atrial cells

Comparison

Intracellular ATP and various kinase/phosphatase… vs Control conditions

Design

Preclinical

Authors

Discussion

Hypothesis-generating for phosphorylation in atrial K+ channel regulation; leaves open translation to human arrhythmias.

Population

Rat neonatal atrial cells

Intervention

Intracellular ATP and various kinase/phosphatase modulators (e.g., Ca2+, sodium vanadate, alkaline phosphatase) during patch-clamp recording

Comparator

Control conditions (e.g., absence of ATP, Mg2+-free solution)

Outcome

Acetylcholine-activated K+ channel kinetics (mean open time [tau o] and mean closed time [tau c]) and channel activitysurrogate

Acetylcholine-activated K+ channels in rat atrial cells undergo desensitization that is modulated by phosphorylation and dephosphorylation processes.

D Kim (1991) studied this question.

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