Key result
Extracellular ATP (10 microM) significantly increased the spontaneous opening frequency of alpha-bungarotoxin-sensitive ACh channels in rat skeletal muscle cells from 0.3 to 4.7 s-1.
Population
Dissociated rat skeletal muscle cells
Comparison
Extracellular adenosine 5'-triphosphate vs Baseline spontaneous activity and other…
Design
Preclinical
Authors
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ATP boosts spontaneous ACh channel activity in vitro; leaves open physiological role in neuromuscular transmission.
Absolute Event Rate: 4.7% vs 0.3%
Extracellular ATP in the micromolar range facilitates both spontaneous and agonist-activated ACh channel opening in rat skeletal muscle cells by increasing channel opening frequency.
Lü et al. (1991) studied Rat skeletal muscle cells. Extracellular adenosine 5'-triphosphate (ATP) vs. Baseline (spontaneous opening) was evaluated on Spontaneous opening frequency on the alpha-bungarotoxin-sensitive ACh channel. Extracellular ATP (10 microM) significantly increased the spontaneous opening frequency of alpha-bungarotoxin-sensitive ACh channels in rat skeletal muscle cells from 0.3 to 4.7 s-1.
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