December 1, 1944Acta Physiologica Scandinavica

The Action of Adenosine Triphosphate and Related Compounds on Mammalian Skeletal Muscle.1

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Population

Cat tibialis anterior muscle model (and frog muscle comparison)

Design

Preclinical

Authors

FBFritz BuchthalUniversity of Copenhagen GKG. KahlsonLund University

Discussion

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Implication

ATP may directly modulate skeletal muscle contraction; animal data leave open translation to human neuromuscular physiology or therapy.

Structured PICO

Population

Cat tibialis anterior muscle model (and frog muscle comparison)

Intervention

Close arterial injection of adenosine triphosphate (ATP) (0.1-1.0 x 10^-6 mol/g muscle) and related compounds (ADP, adenylic acid, sodium tripolyphosphate, pyrophosphate)

Outcome

Muscle contraction (tetanus-like contraction)surrogate

ATP and related phosphate compounds act as direct chemical stimuli to elicit contraction in mammalian skeletal muscle independent of neuromuscular transmission.

Cite This Study

Buchthal et al. (1944) studied this question.

synapsesocial.com/papers/6a98eb59cdb6b1cb7af5a2ba https://doi.org/10.1111/j.1748-1716.1944.tb03070.x

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The Action of Adenosine Triphosphate and Related Compounds on Mammalian Skeletal Muscle.1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Action of Adenosine Triphosphate and Related Compounds on Mammalian Skeletal Muscle.1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider