Population
Isolated frog ventricle
Comparison
Exogenous adenosine 5' triphosphate (ATP) vs Baseline/control levels
Design
Preclinical
Authors
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Requires mammalian validation before clinical consideration; leaves open cyclic nucleotide mediation of inotropy in higher species.
In the isolated frog ventricle, ATP induces a complex triphasic inotropic response that appears to be regulated by changes in the metabolism of cyclic nucleotides and potentially mediated by prostaglandins.
Flitney et al. (1980) studied this question.
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