Key result
Fast desensitization of the muscarinic K+ channel in rat atrial cells requires the presence of ATP and is likely the result of channel dephosphorylation.
Population
Excised patches from rat atrial cells
Comparison
Presence of ATP during activation by ACh or GTP vs Absence of ATP or presence of non-hydrolysable…
Design
Preclinical
Authors
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No immediate clinical implications for atrial arrhythmias; leaves open the role of dephosphorylation in human muscarinic K+ channel regulation.
Fast desensitization of the muscarinic K+ channel in rat atrial cells is ATP-dependent, likely resulting from dephosphorylation of the channel or connecting G protein.
Shui et al. (1997) studied this question. ATP vs. Absence of ATP or AMP-PNP was evaluated on Fast desensitization of the muscarinic K+ channel. Fast desensitization of the muscarinic K+ channel in rat atrial cells requires the presence of ATP and is likely the result of channel dephosphorylation.
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