Key result
Desensitization to acetylcholine in guinea-pig atrial cells involves a fast phase mediated by the G protein or K+ channel and a slow phase involving the muscarinic receptor.
Population
Guinea-pig atrial cells
Design
Preclinical
Authors
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Basic atrial myocyte data warrant caution in clinical translation; leaves open IK,ACh contributions to human AF.
Desensitization to acetylcholine in guinea-pig atrial cells is a biphasic process involving both the muscarinic receptor and the G protein/K+ channel complex.
Zang et al. (1993) studied this question. Acetylcholine (ACh) was evaluated on Desensitization of the ACh-activated K+ current (IK,ACh). Desensitization to acetylcholine in guinea-pig atrial cells involves a fast phase mediated by the G protein or K+ channel and a slow phase involving the muscarinic receptor.
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