August 1, 1989The Journal of PhysiologyOpen Access

Desensitization of the acetylcholine receptor of frog end‐plates measured in a Vaseline‐gap voltage clamp.

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Population

Dissociated frog muscle fibres

Design

Preclinical

Authors

ACA B CachelinUniversity of Bern DCDavid ColquhounUniversity College London

Discussion

Member takes

Implication

Hypothesis-generating for AChR kinetics in low Ca2+; extends amphibian models but leaves open mammalian translation.

Structured PICO

Population

Dissociated frog muscle fibres

Intervention

Acetylcholine (ACh) concentrations between 1 and 1000 microM

Outcome

Desensitization of the nicotinic acetylcholine receptor (time constants and peak response)surrogate

In frog muscle fibres, acetylcholine receptor desensitization is a biphasic process under low intracellular calcium conditions, with time constants largely independent of membrane potential.

Cite This Study

Cachelin et al. (1989) studied this question.

synapsesocial.com/papers/6a209bcc2ad198cbe7f36ab8 https://doi.org/10.1113/jphysiol.1989.sp017717

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Desensitization of the acetylcholine receptor of frog end‐plates measured in a Vaseline‐gap voltage clamp.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Desensitization of the acetylcholine receptor of frog end‐plates measured in a Vaseline‐gap voltage clamp.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider