Population
Frog muscle fibers (Rana pipiens)
Comparison
High extracellular K+ concentration (165 mM) vs Lower extracellular K+ concentration (33 mM)
Design
Preclinical
Authors
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High extracellular K+ may modulate neuromuscular signaling; hypothesis-generating for AChR kinetics and leaves open mammalian translation.
Increases in extracellular K+ can delay acetylcholine receptor desensitization onset independently of effects on transmembrane potential in frog muscle fibers.
A. A. Manthey (1985) studied this question.
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