Why the study?
Does alteration of calcium levels or different cholinoceptor agonists affect the desensitization rate of acetylcholine receptors in denervated rat soleus muscle?
Population
Denervated rat soleus muscle
Comparison
Iontophoretic acetylcholine at high frequency… vs Baseline or control conditions
Design
Preclinical
Authors
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Calcium-independent desensitization in this model; leaves open relevance to human neuromuscular disorders.
Does alteration of calcium levels or different cholinoceptor agonists affect the desensitization rate of acetylcholine receptors in denervated rat soleus muscle?
In denervated rat soleus muscle, the desensitization rate of extrajunctional acetylcholine receptors is not altered by changes in external or intracellular calcium levels.
Anwyl et al. (1980) studied this question.
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