Population
Rat cortical collecting duct (CCD) cells
Design
Preclinical
Authors
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No immediate clinical implications from rat data; extends mechanistic understanding of ATP-PKA effects on collecting duct channels.
ATP exhibits a dual effect on the small-conductance potassium channel in rat cortical collecting ducts, acting as a substrate for PKA at low concentrations to maintain function, while inhibiting channel activity at high concentrations.
Wang et al. (1991) studied this question.
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