Population
Cat ventricular myocytes
Comparison
Exposure to monovalent cations (Na+, Cs+, Li+) vs Absence of specific extracellular cations
Design
Preclinical
Authors
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Cautions against assuming inert cations in IK1 experiments; leaves open translation to human cardiac electrophysiology.
Monovalent cations like Na+, Cs+, and Li+ block cardiac inward-rectifying potassium currents in a time- and voltage-dependent manner, suggesting a common mechanism of action.
Harvey et al. (1989) studied this question.
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