Key result
Contrast-enhanced carotid ultrasound is a safe, non-nephrotoxic method that improves the accuracy of detecting plaque ulceration, determining stenosis severity, and assessing intraplaque neovascularization.
Why the study?
Does contrast-enhanced carotid ultrasound improve the detection of atherosclerotic plaque neovascularization and ulceration?
Does contrast-enhanced carotid ultrasound improve the detection of atherosclerotic plaque neovascularization and ulceration?
Contrast-enhanced carotid ultrasound is a safe, non-nephrotoxic imaging modality that enhances the assessment of atherosclerotic plaque vulnerability by detecting neovascularization and ulceration.
Hypothesis-generating for carotid plaque vulnerability assessment; prospective trials needed before clinical adoption.
Unstable atherosclerotic plaques (ASP) are the cause of acute ischemia in the carotid and coronary systems. Numerous studies have shown a relationship between plaque instability, manifestations, echogenicity, histological findings and its neovascularization. The presence and extent of ASP neovascularization in the carotid arteries can be detected for the first time using contrast-enhanced carotid ultrasound. Contrast-enhanced carotid ultrasound does not have nephrotoxic effect; it also improves the accuracy of plaque ulceration detecting and determining the severity of stenosis. The article presents the opinions of the authors and international experts on contrast ultrasound of peripheral arteries. An analysis of the literature data and our own observations is presented. Significant parameters such as the doses, procedure onset time and duration, methods for the qualitative and quantitative assessment of plaque neovascularization are analyzed. The difficulties of contrast-enhanced ultrasound are described.
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Погорелова et al. (2019) conducted a review in Atherosclerotic plaques in carotid arteries. Contrast-enhanced carotid ultrasound vs. Standard ultrasound was evaluated. Contrast-enhanced carotid ultrasound is a safe, non-nephrotoxic method that improves the accuracy of detecting plaque ulceration, determining stenosis severity, and assessing intraplaque neovascularization.
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