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August 27, 2014Stroke

Contrast-Enhanced Ultrasound for the Evaluation of Neovascularization in Atherosclerotic Carotid Artery Plaques

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Why the study?

Does contrast-enhanced ultrasound with perflubutane accurately evaluate neovascularization in atherosclerotic carotid artery plaques in patients undergoing carotid endarterectomy?

Population

50 consecutive patients who underwent carotid endarterectomy

Design

Cross-sectional

Authors

KSKozue SaitoSuita Municipal HospitalKNKazuyuki NagatsukaJikei University School of MedicineHIHatsue Ishibashi‐UedaHeart Failure & Transplant

Discussion

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Implication

Perflubutane CEUS shoulder intensity was associated with neovessel density and symptoms; hypothesis-generating for noninvasive carotid plaque vulnerability assessment.

Structured PICO

Does contrast-enhanced ultrasound with perflubutane accurately evaluate neovascularization in atherosclerotic carotid artery plaques in patients undergoing carotid endarterectomy?

P
Population
50 consecutive patients who underwent carotid endarterectomy (31 with symptomatic plaques, 19 with asymptomatic plaques)
I
Intervention
Contrast-enhanced ultrasound with perflubutane
O
Outcome
Correlation between contrast effect (enhanced intensity) and histopathology (neovessel density)surrogate

Contrast-enhanced ultrasound with perflubutane can quantitatively assess neovascularization in carotid plaque shoulders, which correlates with histopathology and may help stratify plaque vulnerability.

Cite This Study

Saito et al. (2014) studied this question.

synapsesocial.com/papers/6a70968335aa2c282ce1e86bhttps://doi.org/10.1161/strokeaha.114.006483
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contrast-Enhanced Ultrasound Imaging of Intraplaque Neovascularization in Carotid Arteries2008 · 334 citations
  2. 2Correlation of Carotid Plaque Neovascularization Detected by Using Contrast-enhanced US with Clinical Symptoms2009 · 170 citations
  3. 3Assessment of Carotid Plaque Stability Based on the Dynamic Enhancement Pattern in Plaque Components With Multidetector CT Angiography2011 · 51 citations
  4. 4Carotid Plaque Neovascularization and Hemorrhage Detected by MR Imaging are Associated with Recent Cerebrovascular Ischemic Events2011 · 137 citations
  5. 5The Vulnerable Carotid Artery Plaque2005 · 249 citations