Key result
A 12-year-old girl with a PRKAR1A mutation typical of Carney complex developed multiple recurrent cardiac myxomas in three chambers three years after initial surgical resection.
Highlights a rare presentation of recurrent multi-cameral cardiac myxomas in a pediatric patient with Carney complex.
Pediatric Carney complex patients need extended post-resection surveillance; extends sparse data on multi-chamber myxoma recurrence.
Cardiac myxoma is a relatively rare tumour, usually solitary, that occurs primarily in the left atrium of adults, but comprises only 30% of cardiac tumours in children. We recently treated a 12-year-old girl with multiple recurrent myxomas in three cardiac chambers(following surgical resection 3 years earlier). Genomic analysis showed the PKAR1A mutation typical for Carney complex.
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Burgos et al. (2023) studied this question. A 12-year-old girl with a PRKAR1A mutation typical of Carney complex developed multiple recurrent cardiac myxomas in three chambers three years after initial surgical resection.
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