Atrioventricular valve failure in patients undergoing Fontan palliation was associated with a significantly higher risk of Fontan failure (HR 2.43; 95% CI 1.74-3.39; p<0.001).
Cohort (n=1,468)
Yes
Does atrioventricular valve failure increase the risk of Fontan failure in patients undergoing Fontan palliation?
Atrioventricular valve failure is common after Fontan palliation and is associated with a more than twofold increased risk of subsequent Fontan failure.
Hazard Ratio: 2.43 (95% CI 1.74–3.39)
Absolute Event Rate: 54% vs 77%
p-value: p=< 0.001
BACKGROUND Atrioventricular valve failure (moderate or greater regurgitation, or valve operation) is a risk factor for adverse outcomes in patients undergoing Fontan palliation. OBJECTIVES This study determined the incidence of atrioventricular valve failure and its clinical impact on patients undergoing Fontan palliation. METHODS A retrospective cohort longitudinal study was conducted using patient data extracted from an existing bi-national, population-based registry. RESULTS A total of 1,468 patients who underwent Fontan palliation were identified; complete follow-up data were available for 1,199 patients. Six hundred eighty-six patients had 2 atrioventricular valves, 286 had a single mitral valve, 130 had a common atrioventricular valve, and 97 had a single tricuspid valve. A total of 132 repairs were performed in 110 patients, and 15 replacements were performed in 13 patients. The cumulative incidence of atrioventricular valve failure at 25 years of age for patients with a common atrioventricular, single tricuspid, single mitral, and 2 atrioventricular valves was 56% (95% confidence interval CI: 46% to 67%), 46% (95% CI: 31% to 61%), 8% (95% CI: 4% to 12%), and 26% (95% CI: 21% to 30%), respectively. In patients without valve failure, freedom from Fontan failure at 10 and 20 years post-Fontan palliation was 91% (95% CI: 89% to 93%) and 77% (95% CI: 73% to 81%), respectively, compared with 77% (95% CI: 69% to 85%) and 54% (95% CI: 42% to 68%), respectively, in patients with valve failure (hazard ratio: 2.43; 95% CI: 1.74 to 3.39; p < 0.001). CONCLUSIONS Atrioventricular valve failure occurs frequently in patients undergoing Fontan palliation. Patients with valve failure are twice as likely to have their Fontan circulation fail than those without valve failure.
King et al. (Fri,) conducted a cohort in Fontan palliation (n=1,468). Atrioventricular valve failure vs. No atrioventricular valve failure was evaluated on Freedom from Fontan failure at 20 years (HR 2.43, 95% CI 1.74 to 3.39, p=< 0.001). Atrioventricular valve failure in patients undergoing Fontan palliation was associated with a significantly higher risk of Fontan failure (HR 2.43; 95% CI 1.74-3.39; p<0.001).