Key result
CABG plus mitral valve surgery shows no survival benefit over CABG alone in moderate IMR.
Why the study?
The study was conducted to systematically evaluate the effect of CABG alone versus CABG combined with mitral valve surgery on post-operative survival in patients with moderate ischemic mitral valve regurgitation.
Does coronary artery bypass grafting combined with mitral valve surgery improve post-operative survival compared to CABG alone in patients with moderate ischemic mitral regurgitation?
Meta-Analysis (n=4,476)
Does coronary artery bypass grafting combined with mitral valve surgery improve post-operative survival compared to CABG alone in patients with moderate ischemic mitral regurgitation?
Adding mitral valve surgery to CABG does not improve short- or long-term survival in patients with moderate ischemic mitral regurgitation compared to CABG alone.
Answers are grounded in this paper and cite their sources.
Supports CABG alone in moderate ischemic MR; confirms no survival benefit from adding mitral valve surgery.
Objective:The objective of the study was to systematically evaluate the effect of coronary artery bypass grafting (CABG) or CABG combined with mitral valve surgery (cMVS) on post-operative survival in patients with moderate ischemic mitral valve regurgitation.Materials and methods: Databases including PubMed, Web of Science, COCHRANE LIBRARY, WanFang Data, and CNKI Data were searched from inception to January 2020.According to the inclusion criterion, relevant articles were screened.After that we extracted data, assessed quality, and performed meta-analysis using RevMan 5.2.Results: A total of 4 randomized controlled trial and 14 retrospective study involving 4476 patients were included in the study.The CABG group was 2278 and the cMVS group was 1698.The results of meta-analysis showed that compared with CABG group, there were no statistically significant differences in the recent mortality (odds ratio [OR] = 0.88, p = 0.62), 1-year survival (OR = 1.03, p = 0.82), 1-year survival (OR = 1.07, p = 0.62), and long-term survival (OR = 0.95, p = 0.61) of the cMVS group.Conclusion: Current evidence indicates that patients in the cMVS group did not benefit from CABG group in survival after surgery.
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Lv et al. (2023) conducted a meta-analysis in Moderate ischemic mitral valve regurgitation (n=4,476). CABG combined with mitral valve surgery (cMVS) vs. CABG alone was evaluated on Perioperative mortality (OR 0.88, 95% CI 0.54-1.44, p=0.62). CABG combined with mitral valve surgery did not significantly improve perioperative mortality (OR 0.88) or long-term survival compared to CABG alone in patients with moderate ischemic mitral regurgitation.
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