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Nowadays, technology is developing so rapidly that it implicitly drives economic growth by increasing the productivity of artificial products. Endocrine disruptors (EDs) are increasingly recognized as emerging contaminants in cosmetic formulations, raising concerns about their ability to alter hormonal homeostasis through long-term, low-dose exposure. The objective of this systematic review is to synthesize current evidence on the presence, mechanisms of action, and health effects of endocrine-disrupting chemicals commonly found in cosmetic formulations, as well as existing regulatory frameworks and gaps in consumer protection. A systematic search across major scientific databases for studies published between 2000 and March 2026 was conducted in accordance with PRISMA guidelines, yielding 102 eligible studies. The most commonly identified endocrine disruptors were parabens, phthalates, benzophenones, and triclosan. Evidence shows that these compounds can mimic or block endogenous hormones, disrupt estrogenic, androgenic, and thyroid pathways, and contribute to reproductive, metabolic, and developmental disturbances. Several studies reported bioaccumulation in human tissues and measurable internal exposure with higher vulnerability in pregnant women and adolescents. Current evidence supports a biologically plausible and clinically relevant association between exposure to cosmetic-derived endocrine disruptors and adverse health outcomes. Despite regulatory progress, major gaps persist in long-term exposure assessment, mixture toxicity, and cumulative real-world risk. Strengthening surveillance, harmonizing international regulations, and encouraging safer cosmetic formulations remain essential to reducing population exposure. Although regulatory measures have been introduced, comprehensive protocols for the use of endocrine disruptors in cosmetics are still under development; additional targeted research is required to refine health risk assessments and strengthen regulatory frameworks.
Popa et al. (Tue,) studied this question.