Key result
Maternal pregestational diabetes linked to persistently higher aortic stiffness and septal thickness in early childhood offspring.
Why the study?
Fetuses of diabetic mothers develop LV hypertrophy and have increased cardiovascular risk, but whether previously documented LV hypertrophy and increased aortic stiffness persisted into early childhood was unknown.
Does maternal pregestational diabetes increase aortic stiffness and left ventricular hypertrophy in offspring during early childhood?
Cohort (n=45)
No
Does maternal pregestational diabetes increase aortic stiffness and left ventricular hypertrophy in offspring during early childhood?
Children of diabetic mothers have persistently increased aortic stiffness and left ventricular hypertrophy into early childhood, suggesting that a diabetic intrauterine environment causes long-term cardiovascular programming.
BACKGROUND: Fetuses of diabetic mothers develop left ventricular (LV) hypertrophy and are at increased long-term risk of cardiovascular disease. In our previous longitudinal study from midgestation to late infancy we showed persistence of LV hypertrophy and increased aortic stiffness compared with infants of healthy mothers, the latter of which correlated with third trimester maternal hemoglobin A1c. In the present study, we reexamined the same cohort in early childhood to determine if these cardiovascular abnormalities persisted. METHODS: Height, weight, and right arm blood pressure were recorded. A full functional and structural echocardiogram was performed with offline analysis of LV posterior wall and interventricular septal diastolic thickness (IVSd), systolic and diastolic function, and aortic pulse wave velocity. Vascular reactivity was assessed using digital thermal monitoring. Participants also completed a physical activity questionnaire. RESULTS: < 0.0001, respectively). CONCLUSIONS: CDMs show persistently increased interventricular septal thickness and aortic stiffness in early childhood.
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Do et al. (2020) conducted a cohort in Left ventricular hypertrophy and aortic stiffness in children of diabetic mothers (n=45). Maternal pregestational diabetes vs. Children of healthy mothers was evaluated on Aortic pulse wave velocity (aortic stiffness) (p=<0.001). Maternal pregestational diabetes was associated with persistently increased aortic stiffness (P<0.001) and interventricular septal thickness (P=0.006) in offspring during early childhood.
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