Key result
Maternal diabetes and periconceptual glycemic control significantly increased fetal septal thickness (p<0.0001) and altered long axis function, suggesting functional adaptation to myocardial hypertrophy.
Why the study?
Does maternal diabetes and periconceptual diabetic control alter fetal ventricular long axis function compared to normal controls?
Population
200 singleton fetuses, including 41 fetuses of diabetic mothers and 159 normal controls, studied…
Comparison
Maternal diabetes vs Contemporaneously studied normal controls
Design
Cross-sectional, Measurements were made off line with the investigators…
Follow-up
Cross-sectional (17 weeks to term)
Authors
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Supports periconceptional glycemic optimization in diabetes; leaves open whether fetal adaptations affect postnatal outcomes.
Cross-Sectional (n=200)
Blinded for analysis
No
Does maternal diabetes and periconceptual diabetic control alter fetal ventricular long axis function compared to normal controls?
p-value: p=<0.0001
Periconceptual diabetic control influences fetal cardiac performance and myocardial hypertrophy, but this hypertrophy is accompanied by functional adaptation rather than primary cardiac dysfunction.
Helena M. Gardiner (2005) conducted a cross-sectional in Maternal diabetes (fetal cardiac function) (n=200). Maternal diabetes and periconceptual HbA1c vs. Normal controls (fetuses of non-diabetic mothers) was evaluated on Ventricular long axis function and septal thickness (p=<0.0001). Maternal diabetes and periconceptual glycemic control significantly increased fetal septal thickness (p<0.0001) and altered long axis function, suggesting functional adaptation to myocardial hypertrophy.
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