Why the study?
Does hypertensive hypervolemic therapy with phenylephrine cause systemic toxicity in patients with delayed ischemic deficits after subarachnoid hemorrhage?
Population
24 consecutive patients with delayed ischemic deficits after aneurysmal subarachnoid hemorrhage, 67% with…
Design
Cohort
Authors
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May support phenylephrine tolerability for post-SAH delayed ischemia with monitoring; leaves open need for randomized confirmation.
Does hypertensive hypervolemic therapy with phenylephrine cause systemic toxicity in patients with delayed ischemic deficits after subarachnoid hemorrhage?
Hypertensive hypervolemic therapy with high-dose phenylephrine can be administered safely with acceptable systemic toxicity in patients with delayed ischemic deficits after subarachnoid hemorrhage, provided close monitoring is performed.
Miller et al. (1995) studied this question.
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