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September 13, 1991Science

Modulation of Cardiac Sodium Channels by cAMP Receptors on the Myocyte Surface

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Population

rat, guinea pig, and frog ventricular myocytes

Design

Preclinical

Authors

LSL.A. SorberaBoston UniversityMMMartin MoradElectrophysiology

Discussion

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Implication

Should not alter arrhythmia management; leaves open extracellular cAMP effects on human cardiac sodium channels.

Structured PICO

P
Population
rat, guinea pig, and frog ventricular myocytes
I
Intervention
extracellular adenosine 3',5'-monophosphate (cAMP)
O
Outcome
sodium current and steady-state availability of the sodium channelsurrogate

Extracellular cAMP modulates cardiac sodium channels via a membrane-delimited mechanism involving a pertussis toxin-sensitive G protein.

Cite This Study

Sorbera et al. (1991) studied this question.

synapsesocial.com/papers/6a209e9e239b4646016d8de5https://doi.org/10.1126/science.1653970
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1β-Adrenergic Inhibition of Cardiac Sodium Channels by Dual G-Protein Pathways1989 · 232 citations
  2. 2Isoproterenol, DBcAMP, and forskolin inhibit cardiac sodium current1989 · 126 citations
  3. 3Atrionatriuretic Peptide Transforms Cardiac Sodium Channels into Calcium-Conducting Channels1990 · 80 citations
  4. 4A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates1985 · 395 citations