Key result
High glucose drives cardiac fibroblast fibrosis and collagen deposition via active TGF-β1 pathways.
Why the study?
Cardiac fibrosis drives diastolic dysfunction in diabetic cardiomyopathy, but mechanisms underlying the cardiac fibroblast phenotype in high-glucose conditions and molecules opposing these pro-fibrotic actions remain key knowledge gaps.
This review highlights the mechanisms driving cardiac fibrosis in diabetic cardiomyopathy and identifies potential therapeutic targets to oppose pro-fibrotic actions in cardiac fibroblasts.
Answers are grounded in this paper and cite their sources.
May inform anti-fibrotic strategies in diabetic cardiomyopathy; leaves open clinical translation from fibroblast models.
Diabetic cardiomyopathy involves remodeling of the heart in response to diabetes that includes microvascular damage, cardiomyocyte hypertrophy, and cardiac fibrosis. Cardiac fibrosis is a major contributor to diastolic dysfunction that can ultimately result in heart failure with preserved ejection fraction. Cardiac fibroblasts are the final effector cell in the process of cardiac fibrosis. This review article aims to describe the cardiac fibroblast phenotype in response to high-glucose conditions that mimic the diabetic state, as well as to explain the pathways underlying this phenotype. As such, this review focuses on studies conducted on isolated cardiac fibroblasts. We also describe molecules that appear to oppose the pro-fibrotic actions of high glucose on cardiac fibroblasts. This represents a major gap in knowledge in the field that needs to be addressed.
No takes yet. Share an insight, caveat, or question.
Levick et al. (2020) conducted a review in Diabetic cardiomyopathy and cardiac fibrosis. High-glucose environment vs. Normal glucose conditions was evaluated. A high-glucose environment induces a pro-fibrotic phenotype in cardiac fibroblasts, resulting in excessive collagen deposition mediated through multiple molecular pathways that culminate in increased active TGF-β1.
Synapse has enriched 10 related papers. Consider them for comparative context: