Key result
Obesity is strongly associated with the development and progression of chronic renal disease through maladaptive glomerular hemodynamics and the release of vasoactive and fibrogenic substances.
Highlights the pathophysiological mechanisms linking obesity to chronic renal disease and cardiovascular morbidity.
Supports obesity as a modifiable CKD risk factor; hypothesis-generating for targeted therapies addressing glomerular hemodynamics.
Obesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease--a widely prevalent but often silent condition. Obesity carries elevated risks of cardiovascular morbidity and mortality besides having an array of metabolic complications. Maladaptive glomerular hemodynamics with increased intraglomerular pressure in association with vasoactive, fibrogenic substances released from adipocytes, in addition to cytokines and hormones, are the key factors in the causation of renal injury and the progression of nephron loss among obese subjects.
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Anil Kumar Saxena (2006) conducted a review in Obesity and chronic renal disease. Obesity was evaluated. Obesity is strongly associated with the development and progression of chronic renal disease through maladaptive glomerular hemodynamics and the release of vasoactive and fibrogenic substances.
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