Key result
Both hypocaloric diet and captopril treatment induced a sharp decrease in obesity-related proteinuria at 12 months (to 0.4 g/24 h and 0.7 g/24 h, respectively).
Why the study?
Does body-weight loss or captopril treatment reduce proteinuria in obese patients?
Population
17 obese patients with proteinuria > 1 g/day, age 34-70 years, 11 females and 6 males.
Comparison
Hypocaloric diets or captopril without dietary… vs Compared to baseline and between the two…
Design
Cohort
Follow-up
12 months
Authors
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Hypocaloric diet or captopril was associated with reduced obesity-related proteinuria; hypothesis-generating and requires RCTs before practice change.
Cohort (n=17)
Does body-weight loss or captopril treatment reduce proteinuria in obese patients?
Absolute Event Rate: 0.4% vs 0.7%
Both weight loss via hypocaloric diet and captopril treatment are effective strategies for reducing obesity-related proteinuria while preserving renal function.
Praga et al. (2008) conducted a cohort in Obesity-associated proteinuria (n=17). Hypocaloric diet vs. Captopril was evaluated on Proteinuria at 12 months (g/24 h). Both hypocaloric diet and captopril treatment induced a sharp decrease in obesity-related proteinuria at 12 months (to 0.4 g/24 h and 0.7 g/24 h, respectively).
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