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July 25, 1980JAMA

Proteinuria During Long-term Captopril Therapy

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Why the study?

Does long-term captopril therapy cause proteinuria in hypertensive patients?

Population

81 hypertensive patients

Design

Cohort

Follow-up

at least four months

Authors

DCDavid B. CaseChildren's Hospital Colorado

Discussion

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Implication

Captopril may be associated with early proteinuria that often resolves; leaves open the need for monitoring and causality assessment in larger cohorts.

Key Points

  • To assess the occurrence of proteinuria in hypertensive patients undergoing long-term captopril therapy.
  • Evaluated 81 hypertensive patients on captopril for at least four months.
  • Monitored protein excretion and performed renal biopsy when necessary.
  • Proteinuria developed in 6 of 81 patients (7.4%) after four months of treatment.
  • In 4 patients, proteinuria subsided, while 2 had persistent proteinuria associated with hypoalbuminemia and hypercholesterolemia.
  • Renal biopsy indicated mild membranous nephropathy in 2 patients.

Structured PICO

Does long-term captopril therapy cause proteinuria in hypertensive patients?

P
Population
81 hypertensive patients
I
Intervention
Captopril therapy for at least four months
O
Outcome
Development of proteinuria (protein excretion > 200 mg/24 hr)safety

Long-term captopril therapy can induce proteinuria in a small subset of hypertensive patients, though it frequently subsides even with continued treatment.

Cite This Study

David B. Case (1980) studied this question.

synapsesocial.com/papers/6a726f51ac440176ef2aabcchttps://doi.org/10.1001/jama.1980.03310040028020

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of Chronic Congestive Heart Failure with Captopril, an Oral Inhibitor of Angiotensin-Converting Enzyme1979 · 273 citations
  2. 2STUDIES ON THE MECHANISM OF EXPERIMENTAL PROTEINURIA INDUCED BY RENIN1964 · 50 citations
  3. 3Mechanism of angiotensin II-induced proteinuria in the rat1977 · 200 citations
  4. 4Reversible renal failure during treatment with captopril.1979 · 111 citations
  5. 5Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man1978 · 604 citations