Key result
This review summarizes relevant advances in identifying molecular pathways and genetic variants underlying arterial stiffness from genomic studies.
This review highlights recent genomic advances in understanding the molecular mechanisms and pathways underlying arterial stiffness.
Offers no immediate clinical guidance on arterial stiffness; extends genomic pathway knowledge and leaves open validation studies.
Stiffening of large arteries is a hallmark of vascular aging and one of the most important determinants of the age-related increase in blood pressure and cardiovascular disease events. Despite a substantial genetic component, the molecular mechanisms underlying phenotypic variability in arterial stiffness remain unknown. Previous genetic studies have identified several genetic variants that are associated with measures of arterial stiffness. Here, we review the relevant advances in the identification of pathways underlying arterial stiffness from genomic studies.
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Cecelja et al. (2016) conducted a review in Arterial stiffness. Molecular mechanisms and genomic pathways was evaluated. This review summarizes relevant advances in identifying molecular pathways and genetic variants underlying arterial stiffness from genomic studies.
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