Why the study?
Does a pharmacokinetic/pharmacodynamic Bayesian forecasting computer program using serial prothrombin ratio feedbacks improve the prediction of prothrombin response in inpatients on warfarin therapy?
Population
45 inpatient subjects receiving warfarin therapy
Comparison
Pharmacokinetic/pharmacodynamic Bayesian… vs Predictions based on population parameters alone…
Design
Cohort
Follow-up
until discharge
Authors
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Bayesian forecasting with five prothrombin feedbacks may aid early warfarin predictions; leaves open need for randomized outcome trials.
Does a pharmacokinetic/pharmacodynamic Bayesian forecasting computer program using serial prothrombin ratio feedbacks improve the prediction of prothrombin response in inpatients on warfarin therapy?
A Bayesian forecasting program using four to five serial prothrombin ratio feedbacks provides clinically useful and accurate predictions of prothrombin response early in the course of warfarin therapy.
Svec et al. (1985) studied this question.
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