Key result
The human sinus node and paranodal area showed a complex, heterogeneous pattern of ion channel expression compared to the right atrium, which successfully produced pacemaking in a mathematical model.
Population
6 human tissue samples (sinus node, paranodal area, and right atrium)
Comparison
Analysis of mRNA and protein expression for 120… vs Right atrium and paranodal area
Design
Preclinical
Authors
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Should not yet guide sinus node therapies; leaves open ion channel targets for arrhythmia models.
The human sinus node has a distinct molecular architecture of ion channel expression that explains its pacemaking ability.
Chandler et al. (2009) studied this question. Sinus node and paranodal area vs. Right atrium was evaluated on Expression of ion channels. The human sinus node and paranodal area showed a complex, heterogeneous pattern of ion channel expression compared to the right atrium, which successfully produced pacemaking in a mathematical model.
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