Key result
Microvascular disease is linked to ~270% higher amputation risk, rising synergistically when combined with PAD.
Why the study?
The mechanism of adverse limb events associated with peripheral artery disease remains incompletely understood, particularly the role of microvascular disease in amputation risk.
Does the presence of microvascular disease increase the risk of amputation in patients with or without peripheral artery disease?
Cohort (n=125,674)
Does the presence of microvascular disease increase the risk of amputation in patients with or without peripheral artery disease?
Hazard Ratio: 3.7 (95% CI 3–4.6)
Microvascular disease independently increases the risk of amputation and acts synergistically with peripheral artery disease to further elevate this risk.
No takes yet. Share an insight, caveat, or question.
May warrant closer amputation surveillance in veterans with combined disease; leaves open whether microvascular therapies alter outcomes.
Beckman et al. (2019) conducted a cohort in Peripheral artery disease and microvascular disease (n=125,674). Microvascular disease vs. No peripheral artery disease or microvascular disease was evaluated on Incident amputation (HR 3.7, 95% CI 3.0-4.6). Microvascular disease alone increased amputation risk 3.7-fold (95% CI 3.0-4.6) compared to no disease, and synergistically increased risk 22.7-fold when combined with peripheral artery disease.
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