Key result
Averaging 800 Holter beats is linked to improved late potential detection in post-MI VT.
Why the study?
Although the noise level of Holter-based late potentials is higher than conventional real-time recordings, reducing noise severity by increasing averaging beats had not been investigated.
Does increasing the averaging beats from 250 to 800 improve the diagnostic accuracy and sensitivity of Holter-based late potentials for detecting ventricular tachycardia in patients with prior myocardial infarction?
Observational (n=190)
No
Does increasing the averaging beats from 250 to 800 improve the diagnostic accuracy and sensitivity of Holter-based late potentials for detecting ventricular tachycardia in patients with prior myocardial infarction?
Increasing the number of signal averaging beats to 800 during Holter monitoring improves the signal-to-noise ratio and enhances the identification of patients at risk for fatal ventricular arrhythmias post-myocardial infarction.
Answers are grounded in this paper and cite their sources.
May enhance Holter late-potential detection in post-MI VT; hypothesis-generating and requires prospective validation before clinical adoption.
BACKGROUND: The prevalence of Holter-based late potentials (H-LPs) in cases of fatal cardiac events has increased. Although the noise level of H-LP is higher than that of conventional real-time late potential (LP) recording, a procedure to reduce the noise severity in H-LP by increasing the averaging beats has not been investigated. METHODS: We enrolled 104 patients with post-myocardial infarction (MI) and 86 control participants. Among the patients, 30 reported sustained ventricular tachycardia (VT), and the remaining 74 had unrecorded VT. H-LPs were measured twice in all groups to evaluate the efficacy of increasing the averaging beats for H-LPs. Thereafter, the average of LP was calculated at 250 (default setting), 300, 400, 500, 600, 700, and 800 beats. RESULTS: Across all three groups (MI-VT group, MI non-VT group, and control group), the noise levels significantly decreased in consonance with the increase in averaging beats. In the MI-VT group, the H-LP positive rate considerably increased with the increase in the averaging beats from 250 to 800 both at night and daytime. In the MI-VT group, the LP parameters significantly deteriorated, which led to a positive judgment corresponding to the increment of the averaged night and day beats. The H-LP positive rates were unchanged in the MI non-VT and control groups, while the LP parameters remained consistent, despite the increased averaging beats in the MI non-VT and control groups. CONCLUSION: Increasing the calculated averaging beats in H-LPs can improve the sensitivity of predicting fatal cardiac events in patients with MI.
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Hashimoto et al. (2023) conducted an observational in Post-myocardial infarction with or without sustained ventricular tachycardia, and healthy controls (n=190). Increasing averaging beats in Holter-based late potentials (up to 800 beats) vs. Default signal averaging of 250 beats was evaluated on Holter-based late potential (H-LP) positive rate in the MI-VT group at night using 800 vs 250 averaging beats (p=0.008). Increasing Holter-based late potential averaging beats from 250 to 800 significantly reduced noise and improved the positive detection rate in post-myocardial infarction patients with ventricular tachycardia (p=0.008).
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