Why the study?
Does troglitazone reduce carotid arterial wall thickness in Japanese subjects with type 2 diabetes?
Population
135 Japanese subjects with type 2 diabetes
Comparison
Troglitazone 400 mg daily for 6 months vs Control group (n=78)
Design
Cohort
Follow-up
6 months
Authors
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May indicate slowed atherosclerosis with troglitazone; hypothesis-generating and should not change practice without randomized confirmation.
Does troglitazone reduce carotid arterial wall thickness in Japanese subjects with type 2 diabetes?
Troglitazone significantly reduces carotid intima-media thickness in patients with type 2 diabetes, suggesting an inhibitory effect on early atherosclerosis progression.
Minamikawa et al. (1998) studied this question.
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