Key result
Actin modulates the equilibrium between pre- and post-power stroke conformations of myosin II by no more than 2-fold in the presence of nucleoside triphosphate.
Actin modulates the equilibrium between pre- and post-power stroke conformations of myosin II by no more than 2-fold, suggesting it activates another process such as switch 1 movement and Pi release rather than directly influencing the switch 2 equilibrium.
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Animal data limit actin's direct role in myosin switch 2; hypothesis-generating for Pi release pathways in cardiac muscle.
Conibear et al. (2004) studied this question. Actin was evaluated on Fluorescence properties of myosin II constructs. Actin modulates the equilibrium between pre- and post-power stroke conformations of myosin II by no more than 2-fold in the presence of nucleoside triphosphate.
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