Key result
This article provides a comprehensive review of the kinetics of the actin-myosin interaction, covering crossbridge cycles, ATPase rates, and structural models.
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Design
Review
Provides updated synthesis of cardiac actin-myosin kinetics; leaves open targeted interventions for contractile dysfunction.
The sections in this article are: Crossbridges and Sliding Filaments Regulation Myosin and Actomyosin ATPase Rates of Specific Steps Energetics of Specific Steps Cardiac versus Skeletal Actomyosin ATPase The Crossbridge Cycle in Muscle Energy Transduction and Muscle Mechanics Transient Kinetics in Fibers Using Caged Compounds Analysis of Specific Steps Cardiac Muscle In Vitro Motility Atomic Structures of Actin and Myosin Myosin S1 Actomyosin Comparison of Structural Models to Other Models Recent Progress Regulation The Steric Blocking Model Kinetic Regulation Dual Regulation of the Crossbridge Cycle Phosphorylation and Protein Isoform Switching Summary and Concluding Comments
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Jeffery W. Walker (2002) reported a review. This article provides a comprehensive review of the kinetics of the actin-myosin interaction, covering crossbridge cycles, ATPase rates, and structural models.
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