Key result
The rate-limiting step of actomyosin ATPase in solution determines the rate of force-generation in muscle, and calcium regulates the transition from weak-binding to strong-binding states.
Population
single skinned rabbit psoas fibers
Design
Preclinical
Authors
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Guides mechanistic models of cardiac contractility; leaves open translation to human therapies.
The study confirms that the rate-limiting step of actomyosin ATPase in solution determines the rate of force-generation in muscle, with calcium regulating the transition to force-generating states.
Bernhard Brenner (1986) conducted a review in Muscle physiology (basic science). Calcium concentration variations was evaluated on Cross-bridge kinetics and force generation. The rate-limiting step of actomyosin ATPase in solution determines the rate of force-generation in muscle, and calcium regulates the transition from weak-binding to strong-binding states.
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