October 1, 1990European Journal of Biochemistry

A comparison of the effect of vanadate on the binding of myosin‐subfragment‐1 · ADP to actin and on actomyosin subfragment 1 ATPase activity

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Population

Proteins (actomyosin subfragment 1 and actin) obtained from rabbit skeletal muscle

Design

Preclinical

Authors

SSSusan J. SmithUniversity of Cambridge EEEvan EisenbergNational Institutes of Health

Discussion

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Implication

Vanadate unlikely to inhibit actomyosin S1 ATPase at physiological levels; leaves open its value as a biochemical probe pending higher-model validation.

Structured PICO

Population

Proteins (actomyosin subfragment 1 and actin) obtained from rabbit skeletal muscle

Intervention

Vanadate ion (Vi) at various concentrations

Outcome

Binding constants of vanadate ion and actin, rates of Vi association and dissociation, and steady-state actomyosin S1 ATPase activitysurrogate

Vanadate ion has little inhibitory effect on actomyosin S1 ATPase activity except at high concentrations (>900 microM).

Cite This Study

Smith et al. (1990) studied this question.

synapsesocial.com/papers/6a20a8369ca8a48788f36f22 https://doi.org/10.1111/j.1432-1033.1990.tb19305.x

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Implication

Vanadate unlikely to inhibit actomyosin S1 ATPase at physiological levels; leaves open its value as a biochemical probe pending higher-model validation.

A comparison of the effect of vanadate on the binding of myosin‐subfragment‐1 · ADP to actin and on actomyosin subfragment 1 ATPase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A comparison of the effect of vanadate on the binding of myosin‐subfragment‐1 · ADP to actin and on actomyosin subfragment 1 ATPase activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider