Population
Muscle cells/fibres
Design
Review
Authors
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Metabolite and Ca2+ changes explain fatigue mechanisms; leaves open targeted interventions for exercise intolerance in cardiac disease.
Muscle fatigue during prolonged activity is driven by metabolic changes (H+, Pi, ADP) and altered calcium handling that collectively reduce force, slow shortening velocity, and prolong relaxation.
Allen et al. (1995) studied this question.
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