Why the study?
Does hyperapobetalipoproteinemia alter the rate of fatty acid incorporation into adipose tissue glycerides compared to normolipidemic controls?
Population
13 patients undergoing thoracotomy, including 8 patients with coronary artery disease and…
Comparison
Hyperapobetalipoproteinemia with coronary artery… vs Normolipidemic controls with valvular heart…
Design
Case-control
Authors
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Reduced adipose fatty acid incorporation may impair chylomicron clearance in hyperapobetalipoproteinemia; hypothesis-generating and should not yet change practice.
Does hyperapobetalipoproteinemia alter the rate of fatty acid incorporation into adipose tissue glycerides compared to normolipidemic controls?
Patients with hyperapobetalipoproteinemia exhibit a significantly reduced rate of fatty acid incorporation into adipose tissue glycerides, providing a potential mechanistic explanation for delayed chylomicron triglyceride clearance in this disorder.
Teng et al. (1988) studied this question.
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