Changes in the metabolism of fatty acids in adipose tissue in obese patients with primary hypertriacylglycerolemia.
Why the study?
Does primary hypertriacylglycerolemia alter the release and esterification of free fatty acids in adipose tissue of obese patients?
Population
11 obese subjects, matched for body weight, tolerance of intravenous glucose, fat cell size, fasting levels…
Comparison
In vitro incubation of subcutaneous adipose… vs Adipose tissue from obese normolipidemic subjects
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Reduced adipose FFA re-esterification may increase mobilization in obese HTG; leaves open causal role in primary hypertriacylglycerolemia.
Structured PICO
Does primary hypertriacylglycerolemia alter the release and esterification of free fatty acids in adipose tissue of obese patients?
P
Population
11 obese subjects (5 with moderate primary hypertriacylglycerolemia and 6 normolipidemic controls), matched for body weight, tolerance of intravenous glucose, fat cell size, fasting levels of serum immunoreactive insulin, and serum insulin response to an intravenous glucose load.
I
Intervention
In vitro incubation of subcutaneous adipose tissue with [1-14C]palmitic acid for 30, 60, and 120 min
C
Comparator
Adipose tissue from obese normolipidemic subjects
O
Outcome
Changes in the release and esterification of free fatty acids (FFA) in adipose tissue, including rate of FFA mobilization, glycerol release, re-esterification of FFA, and incorporation into triacylglycerols and tissue FFAsurrogate
Obese patients with primary hypertriacylglycerolemia exhibit decreased esterification of free fatty acids to triacylglycerol in adipose tissue, resulting in increased FFA mobilization.
Cite This Study
Arner et al. (1982) studied this question.