What question did this study set out to answer?

This research focuses on calculating the free energy from ATP hydrolysis in the sarcoplasm under various conditions.

December 23, 1969Proceedings of the Royal Society of London. Series B, Biological sciences

Free energy and enthalpy of ATP hydrolysis in the sarcoplasm

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Implication

May inform models of myocardial energetics; leaves open validation in physiological settings.

Key Points

This research focuses on calculating the free energy from ATP hydrolysis in the sarcoplasm under various conditions.
Discussed factors affecting free energy calculation, including intracellular pH and reactant activities.
Considered thermodynamic data for related reactions and their temperature dependence.
Addressed deviations from equilibrium during muscle contraction.
Demonstrated that all factors must be considered for an accurate free energy calculation.
Outlined a methodology for estimating free energy that incorporates in vitro thermodynamic measurements.

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Outcome

Calculation of free energy available in vivo from ATP hydrolysis

Provides a theoretical framework for calculating the free energy of ATP hydrolysis in the sarcoplasm using recent in vitro thermodynamic measurements.

Cite This Study

A 1969 study studied this question.

synapsesocial.com/papers/6a20aa777cf5d95c4e72e262 https://doi.org/10.1098/rspb.1969.0097

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Free energy and enthalpy of ATP hydrolysis in the sarcoplasm

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Free energy and enthalpy of ATP hydrolysis in the sarcoplasm

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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