Why the study?
Do isoprenaline and dobutamine elicit differential chronotropic, inotropic, and cyclic AMP responses in cat atrial versus ventricular tissue?
Do isoprenaline and dobutamine elicit differential chronotropic, inotropic, and cyclic AMP responses in cat atrial versus ventricular tissue?
Cat atrial tissue exhibits greater sensitivity to beta-adrenergic agonists (isoprenaline and dobutamine) than ventricular tissue, particularly for chronotropic and cyclic AMP responses.
Cat data suggest chamber-specific beta-adrenergic effects; leaves open translation to human myocardium.
Cat atrial tissue was more sensitive to isoprenaline (USP:isoproterenol) and dobutamine than ventricular tissue. Chronotropic response of atrial strips occurred at lower agonist concentrations than inotropic responses of papillary muscle. Cyclic AMP responses in atrial slices also occurred at lower agonist concentrations and were of much greater magnitude than the cyclic AMP responses in ventricular slices. However, the disporportionately greater sensitivity of atrial tissue was more marked with isoprenaline than with dobutamine.
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Tuttle et al. (1976) studied this question.
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