Describes a surgical technique to induce congestive heart failure in guinea pigs for biochemical and enzymologic studies.
May facilitate biochemical heart failure studies in guinea pigs; leaves open translation to other models or clinical relevance.
Summary and conclusionAn operative technic has been described which causes development of congestive heart failure in the guinea pig within 8 to 12 days. Essentially the technic involves intrathoracic incision and restriction of aortic blood flow by ligature surrounding the aorta. Tissues derived from this preparation may be subjected to biochemical and enzymologic studies because of feasibility of preparing slices, homogenates, cell free suspensions and isolated particles. Preliminary biochemical work has been accomplished with this preparation.
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Menard M. Gertler (1959) studied this question.
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